Images play a central role in human perception and understanding of our environment. In the same way, Cyber-Physical Systems (CPS) need visual context and awareness to make autonomous and correct decisions, and eventually take appropriate actions. However, advanced image and video processing is compute intensive and challenging. FitOptiVis was an ECSEL JU project coordinated by PHILIPS MEDICAL SYSTEMS NEDERLAND that brought together a consortium of 31 partners. It balanced power demand versus performance of the increasingly complex distributed configurations in CPS, reflected in the growing number of sensors, actuators and other smart devices, their growing autonomy, and the increased need for performance. This complexity increases even more when multiple heterogeneous sensor inputs are combined for analysis and through integration of both generic and specialised devices. On top of that, CPS need to satisfy rigorous constraints on real-time behaviour, safety, security, reliability, quality, performance and energy consumption. FitOptiVis provided end-to-end multi-objective optimisation for imaging and video pipelines of CPS, with an emphasis on the latter two elements – energy and performance.